Coenzyme Q homeostasis in aging: Response to non-genetic interventions

Coenzyme Q (CoQ) is a key component for many essential metabolic and antioxidant activities in cells mitochondria cell membranes. Mitochondrial dysfunction one of the hallmarks aging age-related diseases. Deprivation CoQ during can be cause or consequence this mitochondrial dysfunction. In any case, it seems clear that aging-associated deprivation accelerates these Non-genetic prolongevity interventions, including dietary supplementation, increase levels membranes improving activity delaying tissue deterioration by oxidative damage. review, we discuss importance diseases effect interventions on synthesis CoQ-dependent activities.